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관심분야

MR biophysics 
Neuroimaging 
Systems Neuroscience 


a) the development of physiological and functional MRI techniques, 
b) the investigation of biophysical and physiological sources of MRI signals (functional MRI, perfusion, diffusion, chemical exchange MRI), and 
c) the application of neuroimaging techniques to systems neuroscience research.

학력

  • (Ph.D.) Physical Chemistry, Washington University St. Louis, MO

약력/경력

  • 전 미네소타대학교 교수
  • 전 피츠버그이미징센터장
  • 폴 로터버(Paul C. Lauterbur) 석좌교수
  • 현 기초과학연구원 뇌과학이미징연구단장, 성균관대학교 BME학과 교수

학술지 논문

  • (2022)  Thrombin Preconditioning Improves the Therapeutic Efficacy of Mesenchymal Stem Cells in Severe Intraventricular Hemorrhage Induced Neonatal Rats.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  23,  8
  • (2022)  Dissection of brain-wide resting-state and functional somatosensory circuits by fMRI with optogenetic silencing.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  119,  4
  • (2021)  Neural mechanisms of pain relief through paying attention to painful stimuli.  PAIN PHYSICIAN.  163,  6
  • (2021)  Role of chemical exchange on the relayed nuclear Overhauser enhancement signal in saturation transfer MRI.  MAGNETIC RESONANCE IN MEDICINE.  87,  1
  • (2021)  Improvement of sensitivity and specificity for laminar BOLD fMRI with double spin-echo EPI in humans at 7 T.  NEUROIMAGE.  241,  -
  • (2021)  Characterization of brain-wide somatosensory BOLD fMRI in mice under dexmedetomidine/isoflurane and ketamine/xylazine.  SCIENTIFIC REPORTS.  11,  1
  • (2021)  Layer-dependent functional connectivity methods.  PROGRESS IN NEUROBIOLOGY.  207,  -
  • (2021)  Differential contribution of excitatory and inhibitory neurons in shaping neurovascular coupling in different epileptic neural states.  JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM.  .,  .
  • (2021)  Contribution of Excitatory and Inhibitory Neuronal Activity to BOLD fMRI.  CEREBRAL CORTEX.  31,  9
  • (2021)  Mapping functional gradients of the striatal circuit using simultaneous microelectric stimulation and ultrahigh-field fMRI in non-human primates.  NEUROIMAGE.  236,  -
  • (2021)  An equal-TE ultrafast 3D gradient-echo imaging method with high tolerance to magnetic susceptibility artifacts: Application to BOLD functional MRI.  MAGNETIC RESONANCE IN MEDICINE.  85,  4
  • (2021)  Rapid three-dimensional steady-state chemical exchange saturation transfer magnetic resonance imaging.  MAGNETIC RESONANCE IN MEDICINE.  85,  3
  • (2021)  Early fMRI responses to somatosensory and optogenetic stimulation reflect neural information flow.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  118,  11
  • (2021)  MRI Compatible, Customizable, and 3D-Printable Microdrive for Neuroscience Research.  ENEURO.  8,  2
  • (2021)  Excitatory neuronal CHD8 in the regulation of neocortical development and sensory-motor behaviors.  CELL REPORTS.  34,  8
  • (2021)  Characteristics of fMRI responses to visual stimulation in anesthetized vs. awake mice.  NEUROIMAGE.  226,  .
  • (2021)  Characteristics of fMRI responses to visual stimulation in anesthetized vs. awake mice of fMRI responses to visual stimulation in anesthetized vs. awake mice.  NEUROIMAGE.  226,  .
  • (2021)  Postsynaptic activity of inhibitory neurons evokes hemodynamic fMRI responses.  NEUROIMAGE.  225,  .
  • (2021)  Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling.  PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES.  376,  1815
  • (2020)  Excitation-Inhibition Imbalance Leads to Alteration of Neuronal Coherence and Neurovascular Coupling under Acute Stress.  JOURNAL OF NEUROSCIENCE.  40,  47

학술회의논문

  • (2015)  Mapping Layer-Specific Neural Activity in the Olfactory Bulb with fMRI.  Brain Conference 2015.  대한민국
  • (2015)  Neural Activity and the Hemodynamic Response.  NeuroFutures2015 Conference.  미국
  • (2015)  Pre-clinical Neuroimaging.  The 3rd ICMRI & The 20th Annaual Scientific Meeting of KSMRM.  대한민국
  • (2015)  Functional imaging of single cell to whole brain.  IPIU2015(Image Processing & Image Understanding).  대한민국
  • (2014)  Physiological MR Imaging for Pre-clinical Research.  제1회 DGMIF 실험동물센터 심포지엄 Preclinical in vivo Imaging.  대한민국
  • (2014)  Non-invasive MR imaging of brain function and metabolism.  International Scientific Symposium _What technology can achieve to help public health in Korea and globally?.  대한민국
  • (2014)  Functional MRI: Spatial Localization.  4th SKKU-NU Annual Workshop on NANO/BIO/PLASMA at SKKU.  대한민국
  • (2014)  Longitudinal changes in resting state functional connectivity by cocaine in rhesus monkeys.  2014 Society of Neuroscience.  미국
  • (2014)  Noninvasive Imaging of Brain for Neuroscience Research.  IBS-ROYAL SOCIETY Research Conference.  대한민국
  • (2014)  Chemical Exchange Saturation Transfer(CEST) Imaging of the Molecular Progression of Neuronal Loss in a Parkinson’s Disease Rat Model.  The Joint Annual Meeting ISMRM-ESMRMB 2014.  이탈리아
  • (2014)  Contributions of excitatory and inhibitory neural activities to BOLD and CBV fMRI.   The Joint Annual Meeting ISMRM-ESMRMB 2014.  이탈리아
  • (2014)  Effects of Chronic Ocular Hypertension and Hypotensive Drug Treatment on Ocular Physiology and Biotransport Using Dynamic Gadolinium-Enhanced MRI.  The Joint Annual Meeting ISMRM-ESMRMB 2014.  이탈리아
  • (2014)  Effects of Chronic Ocular Hypertension on Microstructural Integrity of the Visual System Using Diffusion Tensor MRI.  The Joint Annual Meeting ISMRM-ESMRMB 2014.  이탈리아
  • (2014)  In Vivo Compressed Sensing fMRI Using Conventional Gradient-Recalled Echo and EPI Sequences.   The Joint Annual Meeting ISMRM-ESMRMB 2014.  이탈리아
  • (2014)  Magic Angle Enhanced MR Microscopy of Fibrous Structures in Normotensive and Hypertensive Eyes Using T2, T2* and T1rho MRI.  The Joint Annual Meeting ISMRM-ESMRMB 2014.  이탈리아
  • (2014)  Prediction of Complex MR Signals of a Single Vein: Potential Advancement to Measurement of Venous Oxygen Saturation and Diameter .   The Joint Annual Meeting ISMRM-ESMRMB 2014.  이탈리아
  • (2014)  Spatiotemporal Characterization of Neurodegeneration in the Visual System Upon Acute and Chronic Optic Neuropathies Using Diffusion Tensor MRI.  The Joint Annual Meeting ISMRM-ESMRMB 2014.  이탈리아
  • (2014)  Spin-Lock MRI of Glucose and Deoxyglucose Concentration Changes in Brain.   The Joint Annual Meeting ISMRM-ESMRMB 2014.  이탈리아
  • (2014)  Structural, Metabolic and Functional Relationships Between the Eye and the Brain in Glaucoma Using Multimodal MRI and Optical Coherence Tomograph.   The Joint Annual Meeting ISMRM-ESMRMB 2014.  이탈리아
  • (2014)  Top Down Influence on the Visual Cortex of the Blind During Auditory Sensory Substitution.  The Joint Annual Meeting ISMRM-ESMRMB 2014.  이탈리아