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관심분야

 Neurovascular Coupling 
 Neurological Disorder 







1) Study the effect of chronic stress on neurovascular coupling at functional and structural level 
2) Study the effect of pathologically heightened neuronal excitation and synchronization on neurovascular coupling at functional and structural level and develop cell-therapy for epilepsy, 
3) Study neurovascular coupling mechanism through neurovascular coupling modulators, such as nitric oxide, carbon monoxide, & glucose, and 4) Develop novel techniques to restore neurovascular coupling dysfunction

학력

  • (Ph.D.) Biomedical Engineering, Northwestern University, Evanston, Illinois

약력/경력

  • 한국물리학회, Nano KOREA 편집위원
  • 한국뇌기능맵핑학회 이사
  • 전 미국 코넬대학교 의과대학 전임교수
  • 현 삼성융합의과학원 겸임교수
  • 현 뇌과학이미징연구단 참여교수, 성균관대학교 글로벌BME 학과장

학술지 논문

  • (2022)  Deep brain stimulation of the anterior nuclei of the thalamus can alleviate seizure severity and induce hippocampal GABAergic neuronal changes in a pilocarpine-induced epileptic mouse brain.  CEREBRAL CORTEX.  1,  1
  • (2021)  Development of an Electrochemical Dual H2S/Ca2+ Microsensor and Its In Vivo Application to a Rat Seizure Model.  ACS SENSORS.  6,  11
  • (2021)  Differential contribution of excitatory and inhibitory neurons in shaping neurovascular coupling in different epileptic neural states.  JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM.  41,  5
  • (2021)  Orthopedic surgery-induced cognitive dysfunction is mediated by CX3CL1/R1 signaling.  JOURNAL OF NEUROINFLAMMATION.  18,  1
  • (2021)  Design and material for a patternable polysiloxane acrylate-based penetrating intracortical neural probe.  JOURNAL OF MICROMECHANICS AND MICROENGINEERING.  31,  3
  • (2020)  Excitation-Inhibition Imbalance Leads to Alteration of Neuronal Coherence and Neurovascular Coupling under Acute Stress.  JOURNAL OF NEUROSCIENCE.  40,  47
  • (2020)  Young consumers' brain responses to pop music on Youtube.  ASIA PACIFIC JOURNAL OF MARKETING AND LOGISTICS.  32,  5
  • (2020)  A Soft Housing Needle Ultrasonic Transducer for Focal Stimulation to Small Animal Brain.  ANNALS OF BIOMEDICAL ENGINEERING.  48,  4
  • (2020)  Supramolecular Peptide Hydrogel-Based Soft Neural Interface Augments Brain Signals through a Three-Dimensional Electrical Network.  ACS NANO.  14,  1
  • (2019)  Neurovascular Coupling under Chronic Stress Is Modified by Altered GABAergic Interneuron Activity.  JOURNAL OF NEUROSCIENCE.  39,  1
  • (2019)  Lipopeptide-Based Nanosome-Mediated Delivery of Hyperaccurate CRISPR/Cas9 Ribonucleoprotein for Gene Editing.  SMALL.  15,  46
  • (2019)  Chronic and acute stress monitoring by electrophysiological signals from adrenal gland..  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  1,  1
  • (2019)  Chronic and acute stress monitoring by electrophysiological signals from adrenal gland.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.  116,  4
  • (2019)  Longitudinal study of hemodynamics and dendritic membrane potential changes in the mouse cortex following a soft cranial window installation.  NEUROPHOTONICS.  6,  1
  • (2018)  Ultrasmall gold nanosatellite-bearing transformable hybrid nanoparticles for deep tumor penetration.  ACTA BIOMATERIALIA.  79, 
  • (2018)  Real-time in vivo two-photon imaging study reveals decreased cerebro-vascular volume and increased blood-brain barrier permeability in chronically stressed mice.  SCIENTIFIC REPORTS.  8, 
  • (2018)  Intracellularly Activatable Nanovasodilators To Enhance Passive Cancer Targeting Regime.  NANO LETTERS.  18,  4
  • (2018)  Protein tyrosine phosphatase conjugated with a novel transdermal delivery peptide, astrotactin 1-derived peptide recombinant protein tyrosine phosphatase (AP-rPTP), alleviates both atopic dermatitis-like and psoriasis-like dermatitis.  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY.  141,  1
  • (2017)  Label-free nanoscale optical metrology on myelinated axons in vivo.  NATURE COMMUNICATIONS.  8, 
  • (2017)  Agmatine Modulates the Phenotype of Macrophage Acute Phase after Spinal Cord Injury in Rats.  EXPERIMENTAL NEUROBIOLOGY.  26,  5

단행본

  • (2010)  융합 인지과학의 프런티어.  성균관대학교 출판부.  공동
  • (2009)  신경과학 뇌의 탐구 제 3 판.  바이오메디북.  공동
  • (2009)  신경생물학 (Mark F Bear, Barry W Connors, Michael A. Paradiso) Neuroscience, Exploring the Brain, Third Edition.  바이오메디북.  공동
  • (2005)  In vivo intrinsic optical signal imaging of neocortical epilepsy..  Totowa, N. J., Humana Press.  공동
  • (2005)  Intrinsic optical signal imaging of normal and abnormal physiology in animals and humans--seeing the invisible.  Clin Neurosurg.  단독

특허/프로그램

  • 투명 생체재료를 이용한 두개골 대체 투명-인공뼈 제조 및 투명 인공뼈 장착 방법.  10-2015-0034628.  20160218.  대한민국
  • 듀얼 태스크 패러다임을 이용한 치매 진단 장치 및 방법.  IP12061903.  20140123.  대한민국
  • 뇌신경-혈류계의 실시간 활성도 측정을 위한 광학 이미징 전문 분석 인터페이스 프로그램 개발.  10-2010-0137115.  20130527.  대한민국
  • 그라핀 뇌신호 전기 자극기 및 검출기 개발.  10-2010-0054454.  20110101.  대한민국

학술회의논문

  • (2019)  Real-time in vivo two-photon imaging study reveals alterations in capillary blood flow and blood-brain barrier permeability in the post-ictal state.  Neuroscience 2019 (SFN).  미국
  • (2019)  Investigation of role of frontal cortex on shaping functional connectivity of cerebral cortex.  Brain 2019.  일본
  • (2019)  Real-time two-photon imaging of hippocampal neuro-vasculature and BBB permeability in chronic temporal lobe epilepsy model.  Brain 2019.  일본
  • (2019)  Real-time two-photon imaging study reveals increased blood-brain barrier permeability in chronically stressed mice.  Brain 2019.  일본
  • (2019)  The long-term effects of systemic inflammation on hemodynamic response in the mouse cortex.  Brain 2019.  일본
  • (2019)  The cortical vasculature of mouse affects the pattern of hemodynamic responses under dual sensory stimulus.  Brain 2019.  일본
  • (2018)  In vivo and ex vivo study of impaired neurovascular coupling in chronically stressed mouse.  Society for Neuroscience.  미국
  • (2018)  Investigation of neuronal correlations with hemodynamic fluctuations in resting state using simultaneous wide-field hemodynamic and calcium imaging.  Society for Neuroscience.  미국
  • (2018)  Longitudinal study of neurovascular coupling changes associated with recovery period following soft cranial window installation in mouse.  Society for Neuroscience.  미국
  • (2018)  Dynamics of neurovascular coupling at a single-neuron and single-vessel level during seizure events.  Society for Neuroscience 2018.  미국
  • (2018)  Real-time in vivo two-photon imaging study reveals increased blood-brain barrier permeability in chronically stressed mice.  Society for Neuroscience.  미국
  • (2018)  Alterations of the cerebrovascular system in acute stress mouse model.  Annual Biophotonics Conference 2018.  대한민국
  • (2018)  Cortical hemodynamic responses under multisensory stimulation.  Annual Biophotonics Conference 2018.  대한민국
  • (2018)  Photoacoustic imaging of hemodynamic responses in sub-cortical region of mouse with whole-brain soft cranial window.  Annual Biophotonics Conference 2018.  대한민국
  • (2018)  Dynamics of neurovascular coupling at a single-vessel and single-neuron level during seizure events revealed by in vivo two-photon imaging.  UK-Korea Neuroscience Symposium A#19.  대한민국
  • (2017)  Nano-Medical 좌장.  10th International Conference on Advanced Materials and Devices (ICAMD2017).  대한민국
  • (2017)  Dynamics of neurovascular coupling between excitatory neurons and adjacent vessels at ictal onset and termination revealed by In vivo two-photon imaging.  Society for Neuroscience 2017.  미국
  • (2017)  The differential patterns of the sensory evoked-hemodynamic response of mouse barrel cortex at two- and six-weeks post soft- cranial window installation.  Society for Neuroscience 2017.  미국
  • (2017)  Deep brain stimulation to anterior thalamic nucleus affects the EEG patterns of pilocarpine-induced chronic temporal lobe epilepsy model.  Society for Neuroscience 2017.  미국
  • (2017)  Installation periods of soft cranial window affects the pattern of sensory evoked-hemodynamic response of mouse barrel cortex..  제 20회 한국뇌신경과학회.  대한민국

전시/발표회

  • (2007)  Decrease in tissue oxygenation during interictal epileptic spikes in rodent model depends on intensity of epileptic activity..  미국, 
  • (2007)  Decrease in tissue oxygenation during interictal epileptic spikes in rodent model depends on intensity of epileptic activity..  미국, 
  • (2007)  Effects of hypoxia and hypotension on local oxygenation during focal neocortical seizures..  미국, 
  • (2007)  Effects of hypoxia and hypotension on local oxygenation during focal neocortical seizures..  미국, 
  • (2007)  Eye-Target Synchrony and attention.  미국, 
  • (2007)  High sensitive optical spectroscopic imaging of perfusion and oximetry signal during spontaneous seizures in chronically developed neocortical epileptic in rodent..  미국, 
  • (2007)  High sensitive optical spectroscopic imaging of perfusion and oximetry signal during spontaneous seizures in chronically developed neocortical epileptic in rodent..  미국, 
  • (2007)  In vivo voltage sensitive dyes imaging of acute seizures and interictal spikes in rat neocortex.  미국, 
  • (2007)  In vivo voltage sensitive dyes imaging of acute seizures and interictal spikes in rat neocortex,.  미국, 
  • (2007)  Measuring attentional deficits in mild TBI patients during predictive smooth pursuit eye tracking with dual-task demands.  미국, 
  • (2007)  Measuring the effect of dual-task demands on predictive smooth pursuit eye movements and their correlations with white matter integrity in mild traumatic brain injury (TBI) patients.  미국, 
  • (2007)  Measuring the effect of dual-task demands on predictive smooth pursuit eye movements and their correlations with white matter integrity in mild traumatic brain injury (TBI) patients..  미국, 
  • (2007)  Optical spectroscopic imaging reveals non-linear relationship among cerebrovascular perfusion, oximetry and direct stimulation parameters.  미국, 
  • (2006)  Measuring variability in mild TBI. James McDonnell Foundation Workshop: Assessing the Theoretical, Diagnostic, and Therapeutic Implications of Individual Performance Variability in Persons with Brain Injury,.  미국, 
  • (2006)  Frequency dependent hemodynamic responses to direct bipolar cortical stimulation..  미국, 
  • (2006)  Impaired smooth pursuit-gap eye movement following mild traumatic brain injury..  미국, 
  • (2006)  Increased perfusion and decreased hemoglobin oxygenation predict the onset of spontaneous seizures in human cortex.  미국, 
  • (2006)  Optical Spectroscopic Imaging, Laser Doppler Flowmetry and Oxygen Microelectrode Recording of Ictal Focus and Surround in Rat Neocortex..  미국, 
  • (2006)  Simultaneous Imaging of Voltage Sensitive Dyes and Intrinsic Optical Signals..  미국, 
  • (2006)  Visualizing Frequency Dependent Hemodynamic Response Changes during Direct Bipolar Cortical Stimulation in the Rat Neocortex.  미국,